All patients had a minimum follow-up of 12 months and no cervical or other recurrences were encountered. A selective neck dissection was performed on these patients and no further metastases were encountered. Introduction: Lymphoscintigraphic planar imaging is a common procedure for sentinel lymph node imaging prior to lymph node biopsy, but fails to elucidate the specific lymphatic drainage. Methods: This prospective, cooperative group trial involved 25 institutions over a 3-year period. Histopathological examination of SLNs revealed micrometastases in two patients. Status of lymph nodes of level IIb was examined to identify the incidence of nodal metastasis and the lymphatic drainage in squamous cell carcinoma of the oral tongue in patients undergoing modified radical neck dissection (MRND) and sentinel node biopsy (SNB). Purpose: The validity of sentinel lymph node biopsy (SLNB) for T1 or T2, clinically N0, oral cancer was tested by correlation of sentinel node pathologic status with that of nodes within the completion neck dissection. The SLNs were cut at 1-2 mm intervals and stained with haematoxylin and eosin and cytokeratin AE1/AE3. Nodal staging may be considered with high-risk cutaneous tumors without palpable lymphadenopathy via imaging and, if negative, sentinel lymph node biopsy. Thirteen consecutive patients with a small T1 oral cavity squamous cell carcinoma, clinically staged NO, and who did not meet the indications for elective neck treatment, underwent SLN biopsy. Nodal metastasis for cutaneous squamous cell carcinoma occurs in 46 of patients and sentinel lymph node biopsy is positive in 29.4 of Brigham and Women's Hospital stage T2b tumors. To examine the benefits of SLN biopsy in oral cancer patients who have a small risk for occult metastasis and therefore are not considered candidates for elective neck treatment. Background: While progress has been made in defining the clinical and histopathologic features of high-risk cutaneous squamous cell carcinoma (HRcSCC), optimal staging guidelines remain elusive. Early detection of node metastasis is a major goal for dermatologists and oncologists. Cutaneous squamous cell carcinoma (cSSC) is one of the most common skin cancers and can lead to patient death. Although sentinel lymph node (SLN) biopsy is not yet validated for clinical use to replace elective neck dissection in patients with oral squamous cell carcinoma, it can be recommended for patients who do not fulfil the criteria for elective neck treatment according to current treatment protocols. The procedure sentinel lymph node biopsy has been proposed to improve early detection of node metastas.
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